8-iso-prostaglandins for glaucoma therapy

Details 8-iso-prostaglandins for glaucoma therapy 8-iso-prostaglandins for glaucoma therapy

A - Human Necessities

61

K

A61K 31/5575 (2006.01) A61P 27/06 (2006.01)

Patent

CA 2293325

The present invention relates to the use of 8-iso prostaglandins and their derivatives for decreasing intraocular pressure, for example in the treatment of glaucoma. It is based, at least in part, on the discovery that 8-iso prostaglandin E2 effectively decreased intraocular pressure by a trabecular meshwork outflow mechanism.

L'invention concerne l'utilisation des 8-iso-prostaglandines et de leurs dérivés pour faire baisser la tension intra-oculaire, par exemple dans le traitement du glaucome. Elle se caractérise, au moins en partie, par la découverte de l'action de la 8-iso-prostaglandine E2, qui fait baisser efficacement la tension intra-oculaire par un mécanisme d'évacuation du trabéculum.

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