88kda tumorigenic growth factor and antagonists

Details 88kda tumorigenic growth factor and antagonists 88kda tumorigenic growth factor and antagonists

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A01N 43/04 (2006.01) A61K 31/70 (2006.01) A61K 31/7088 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 14/475 (2006.01) C07K 16/22 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G01N 33/567 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2290602

This invention relates to products and methods for treating cancer and for diagnosing tumorigenicity and other diseases associated with alteration in GP88 expression or action. Antagonists to an 88KDa autocrine growth and tumorigenicity stimulator are provided which inhibit its expression or biological activity. The antagonists include antisense oligonucleotides and antibodies.

L'invention concerne des produits et des méthodes permettant de traiter le cancer et de diagnostiquer l'action tumorigène et d'autres maladies associées à une altération dans l'expression ou l'action de GP88. L'invention concerne également des antagonistes d'un activateur de la croissance autocrine et l'action tumérogène de 88 Kda, lesdits antagonistes inhibant son expression ou son activité biologique. Ces antagonistes comprennent notamment des oligonucléotides et des anticorps antisens.

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