8beta-substituted ergolines, process for their production...

Details 8beta-substituted ergolines, process for their production... 8beta-substituted ergolines, process for their production...

C - Chemistry, Metallurgy

07

D

260/206, 167/227

C07D 457/00 (2006.01) A61K 31/48 (2006.01) C07D 457/02 (2006.01) C07D 457/06 (2006.01)

Patent

CA 2031510

Abstract Compounds of formula I Image I in which R2 means optionally substituted C1-7 alkyl, C2-7 alkenyl, CH2-O-C1-4 alkyl or CH2-S-C1-4 alkyl R6 means C2-6 alkyl, C3-6 alkenyl or C3-5-cycloalkyl-C1-2 alkyl and RR means CH2-X, Image or CO-NR3-CO NH R4 in which X stands for CN, OCH3, SCH3 or CONH2 and R1 stands for hydrogen, halogen, methyl or methoxy, and R3 and R4 each mean C1-4 alkyl or (CH2)n-N(CH3)2, in which n = 1-4, and their acid addition salts, the process for their production, their use as pharmaceutical agents as well as intermediate compounds are described.

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