(8s)-8-fluoroerythromycin derivatives, the process for the...

C - Chemistry – Metallurgy – 07 – H

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260/230.3

C07H 17/08 (2006.01)

Patent

CA 1229591

ABSTRACT (8S)-8-fluoroerythromycin derivatives of formula Image (I) wherein R is an optionally substituted alkyl, alkenyl or phenyl group R' is hydrogen or methyl and R" is hydrogen or hydroxy, may be prepared by fluorination of the corresponding 8,9-anhydroerythromycin 6,9-hemiketals with perchloryl fluoride in the presence of a compound ROH in strictly anhydrous conditions. The new compounds as well as their pharmaceutically acceptable esters, salts and salt-esters may be employed as the active ingredients of pharmaceutical compositions for antibacterial use suitable for oral administration.

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