9-fluoroprostaglandin derivatives, process for their...

Details 9-fluoroprostaglandin derivatives, process for their... 9-fluoroprostaglandin derivatives, process for their...

C - Chemistry, Metallurgy

07

C

260/235.01

C07C 405/00 (2006.01) A61K 31/557 (2006.01)

Patent

CA 2036386

ABSTRACT The invention relates to 9-fluoroprostaglandin derivatives of formula I, Image (I), in which R1 means --- Image , Image , COOR4 or CONHR5, R2 and R3 each mean a hydrogen atom or a free or functionally modified hydroxy group, X means a CH2 group, an O or S atom, W means hydrogen, -OR6, halogen, -CN-, -NO2, trifluoromethyl or COOR6, and, if R4 means hydrogen, their salts with physiologically compatible bases, the alpha-, beta- or gamma- cyclodextrin clathrates, as well as the compounds of formula I encapsulated with liposomes, process for their production and their pharmaceutical use.

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