C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/52 (2006.01) A61K 35/76 (2006.01) A61K 38/44 (2006.01) A61P 31/04 (2006.01) C12P 13/08 (2006.01)
Patent
CA 2729160
The present disclosure relates to chimeric bacteriophage lysins useful for the identification and/or reduction of staphylococcal populations. For example, a chimeric bacteriophage lysin was engineered and shown to effectively kill all strains of staphylococci tested including antibiotic resistant methicillin-resistant S. aureus and VISA.
La présente invention concerne des lysines chimériques de bactériophage, utiles pour lidentification et/ou la réduction de populations staphylocoques. Par exemple, une lysine chimérique de bactériophage est conçue et il est montré quelle tue de manière efficace toutes les souches de staphylocoques testées, y compris S. aureus et VISA résistantes à la méthicilline et résistantes aux antibiotiques.
Daniel Anu
Euler Chad
Fischetti Vincent A.
Benoit & Cote Associes Inc.
The Rockefeller University
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