A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/396 (2006.01) A61K 31/513 (2006.01) A61K 31/522 (2006.01) A61K 31/675 (2006.01) A61K 31/7068 (2006.01) A61K 38/43 (2006.01) A61K 38/44 (2006.01) A61K 38/45 (2006.01) A61K 38/48 (2006.01) A61K 38/50 (2006.01) A61K 47/30 (2006.01) A61P 35/00 (2006.01) C12N 15/86 (2006.01)
Patent
CA 2519642
The present invention provides a method of treating a solid tumour in a subject, the method comprising the following steps(i) delivering to the solid tumour a composition comprising an engineered ovine atadenovirus; and(ii) administering a prodrug to the subject,wherein the engineered ovine atadenovirus comprises a promoter and a gene encoding an enzyme which converts the prodrug to a cytotoxic metabolite, the gene being under the control of the promoter.
La présente invention concerne un procédé de traitement d'une tumeur solide chez un patient. Ce procédé consiste à (i) délivrer à la tumeur solide une composition contenant un atadénovirus ovin modifié, et (ii) à administrer une prodrogue à un patient. L'atadénovirus ovin modifié comprend un promoteur et un gène codant pour un enzyme qui convertit la prodrogue en un métabolite cytotoxique, le gène étant sous le contrôle du promoteur.
Both Gerald Wayne
Cameron Fiona Helen
Lockett Trevor John
Martiniello-Wilks Rosetta
Moghaddam Minoo Jalali
Commonwealth Scientific And Industrial Research Organisation
Fetherstonhaugh & Co.
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