C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/48 (2006.01) A61K 31/47 (2006.01) A61P 9/10 (2006.01) A61P 17/06 (2006.01) A61P 27/02 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2543650
Disclosed is a crystalline form of the hydrochloride or hydrobromide salt of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinoline- carboxamide, which has excellent characteristics in terms of physical properties and pharmacokinetics, particularly dissolution rate and bioavailability, and thus is useful as an angiogenesis inhibitor or c-Kit kinase inhibitor.
L'invention porte sur des cristaux: d'hydrochlorure, d'hydrobromure, de p-toluènesulfonate, de sulfate, de méthanesulfonate, ou d'éthanesulfonate de 4-(3-chloro-4-(cyclopropylamino-carbonyl)aminophénoxy)-7-méthoxy-6-quinolinecarboxamide, ou sur des cristaux d'un solvate d'un quelconque d'entre eux.
Arimoto Itaru
Ayata Yusuke
Gotoda Masaharu
Kamada Atsushi
Matsushima Tomohiro
Eisai Co. Ltd.
Eisai R&d Management Co. Ltd.
Marks & Clerk
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