A cxc chemokine receptor 4 (cxcr4) antagonistic polypeptide

Details A cxc chemokine receptor 4 (cxcr4) antagonistic polypeptide A cxc chemokine receptor 4 (cxcr4) antagonistic polypeptide

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01)

Patent

CA 2691061

A peptide having the following amino acid sequence: Z1-LVRYTKKVPQVSTPTL-Z2(ALB- 408) and its biolog-ically active fragments and/or variants and/or derivatives, especially amidated, acetylated, sulfated, phosphorylated and/or glyco-sylated derivatives, and peptides obtainable by multiple synthesis which have the biological activity of ALB408-423; wherein Z represents number of from 0 to 10 amino acid residues.

L'invention porte sur un peptide ayant la séquence d'acides aminés suivante : Z1-LVRYTKKVPQVSTPTL-Z2(ALB-408) et sur ses fragments et/ou variants et/ou dérivés biologiquement actifs, notamment des dérivés amidés, acétylés, sulfatés, phosphorylés et/ou glycosylés, et sur des peptides pouvant être obtenus par une synthèse multiple qui ont l'activité biologique d'ALB408-423 ; où Z représente un nombre de 0 à 10 restes d'acide aminé.

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