G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/566 (2006.01) A61K 51/04 (2006.01) G01N 33/52 (2006.01) G01N 33/53 (2006.01) G01N 33/94 (2006.01)
Patent
CA 2404540
The present invention demonstrates that epibatidine binds to nicotinic receptors on leukocytes. Epibatidine is a sensitive detector of increases in the number of nicotinic receptors expressed by a cell. Epibatidine binds to the leukocytes of smokers, but does not bind to the leukocytes of non-smokers. Both in vivo and ex vivo nicotine exposure induces epibatidine receptor expression. Epibatidine binding to leukocytes reflects epibatidine binding in the central nervous system, which in turn reflects nicotine-induced effects on the central nervous system. Epibatidine binding assays in peripheral blood leukocytes can be used to evaluate an individual's exposure to, and dependence on, nicotine.
Changeux Jean Pierre
Cormier Anne
Grailhe Regis Christian
Lagrue Gilbert
C.n.r.s.
Changeux Jean Pierre
College de France
Cormier Anne
Grailhe Regis Christian
LandOfFree
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