A method for producing red blood cells

Details A method for producing red blood cells A method for producing red blood cells

C - Chemistry, Metallurgy

12

N

C12N 5/078 (2010.01) A61K 35/14 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2566561

The invention relates to a method for the expansion and differentiation of haematopoietic stem cells into enucleated erythrocytes, in two steps : a first step in a culture medium, where cell proliferation and erythroid differentiation are induced in the presence of growth factors, and a second step modeling a reconstitution of the microenvironment, substantially without erythropoietin (EPO). Optionally, the method of culture may comprise an intermediate step, with haematopoietic growth factors.

L'invention concerne une méthode pour l'expansion et la différenciation de cellules souches hématopoïétiques en érythrocytes énucléés. Ladite méthode comporte deux étapes. Lors d'une première étape, la prolifération cellulaire et la différenciation érythroïde sont induites dans un milieu de culture en présence de facteurs de croissance et lors d'une seconde étape, une reconstitution du microenvironnement, pratiquement sans érythropoïétine (EPO) est modelée. Facultativement, ladite méthode peut comporter une étape intermédiaire avec des facteurs de croissance hématopoïétiques.

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