C - Chemistry – Metallurgy – 08 – B
Patent
C - Chemistry, Metallurgy
08
B
C08B 37/08 (2006.01)
Patent
CA 2755520
This invention relates to a novel method of preparation of hyaluronic acid derivatives by means of a reaction of the hyaluronic acid with the complex (O-acyl-O'-alkyl carbonate -substituted pyridine) of the general formula R-CO-O-CO-O-R1 and R25C5N. The reaction takes place in DMSO in the presence of an external base, forming O-acylated products. The method leads to higher substitution degrees and shorter reaction times compared to the known analogues, hi case the agent comprises two or more functional groups R(CO-O-CO-O-R1 )n, crosslinked hyaluronic acid derivatives are formed.
Cette invention concerne un nouveau procédé de préparation de dérivés de l'acide hyaluronique par réaction de l'acide hyaluronique avec le complexe (carbonate d'O-acyl-O'-alkyle pyridine substituée) de formule générale R-CO-O-CO-O-R1 et R25C5N. La réaction est mise en uvre dans du DMSO en présence d'une base externe, et forme des produits O-acylés. Le procédé donne des degrés de substitution plus élevés et des temps de réaction plus courts comparativement aux analogues connus. Dans le cas où l'agent comprend deux groupes fonctionnels R(CO-O-CO-O-R1)n ou plus, des dérivés d'acide hyaluronique réticulés sont formés.
Buffa Radovan
Nikodym Pavel
Palek Lukas
Pospisilova Lucie
Pravda Martin
Contipro C. A.s.
Gowling Lafleur Henderson Llp
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