C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/88 (2006.01) A61K 9/127 (2006.01) A61K 31/70 (2006.01) A61K 47/44 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2223637
An improved method for encapsulating high molecular weight nucleic acids in liposomes, which provides for high nucleic acid entrapment efficiencies, is provided. The resulting compositions provide enhanced in vitro and in vivo transfection and are useful, for example, in producing cell lines expressing a desired nucleic acid sequence.
L'invention porte sur un procédé amélioré d'encapsulation d'acides nucléiques de poids moléculaire élevé dans des liposomes, ce qui assure une grande efficacité en matière de piégeage de l'acide nucléique. Les compositions qui en sont issues stimulent une transfection in vitro et in vivo et s'avèrent utiles, par exemple, pour produire des lignées cellulaires exprimant une séquence nucléotidique souhaitée.
Dritschilo Anatoly
Thierry Alain
Georgetown University
Smart & Biggar
LandOfFree
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