A micro-bubble plate for patterning biological and...

C - Chemistry – Metallurgy – 12 – M

Patent

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Details

C12M 1/22 (2006.01) B01L 3/00 (2006.01)

Patent

CA 2625071

Systems and methods for patterning biological and non-biological material at specific sites on a plate, as well as growing three dimensional structures. Preferred embodiments comprise a plate (6) with regions (16) that will trap gas, usually in the form of bubbles (10), when the plate (6) is submerged in liquid. Other embodiments of the present invention include a method for placing materials on the plate (6) at predetermined locations through the use of trapped gas to prevent materials from collecting at unwante regions. The plate (6) has great utility for plating cells and tissues (5) at specific sites, such as on an array. The disclosed method can also be used to coat the surface of a plate (6) at specific locations for patterned coating applications and to build up materials to produce three dimensional structures, including micromechanical structures where the structures may be formed from living or nonliving material, organic or inorganic, and the like.

L'invention porte sur des systèmes et sur des procédés de configuration de matière biologique et non biologique au niveau de sites spécifiques sur une palque, ainsi que sur l'étirement de structures tridimensionnelles. Des formes d'exécution préférées comprennent une plaque pourvue de régions destinées à piéger le gaz, généralement sous forme de bulles, lorsque la plaque est submergée dans un liquide. Des modes de mise en oeuvre de l'invention incluent un procédé visant à placer des matières sur la plaque à des positons prédéterminées au moyen du gaz piégé pour empêcher le rassemblement des matières au niveau de régions non désirées. La plaque est d'une grande utilité pour étaler des cellules et des tissus au niveau de sites spécifiques tels que sur un réseau. Le procédé de l'invention peut être utilisé pour recouvrir la surface d'une plaque à des points spécifiques pour des application configurées et pour former des matériaux afin de produire des structures tridimensionnelles telles que des structures micromécaniques, ces structures pouvant être obtenues à partir de matière vivante ou non vivante, organique ou inorganique et autre.

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