A new process for preparation of imipenem

Details A new process for preparation of imipenem A new process for preparation of imipenem

C - Chemistry, Metallurgy

07

D

C07D 477/20 (2006.01)

Patent

CA 2531578

Disclosed herein is a compound of Formula II below: 0H wherein R1 is a p- nitrobenzyl or p-methoxybenzyl, group; and R2 and R3 may be identical to or different from each other and are each independently a C1-6alkyl or aryl group, or a derivative thereof, and a process for preparing the compound of Formula II. Further disclosed is a process for preparing imipenem of Formula I below: by using the compound of Formula II.

L'invention concerne un composé représenté par la formule générale (II), dans laquelle R¿1? désigne un groupe p-nitrobenzyle ou p-méthoxybenzyle ; et R¿2? et R¿3? peuvent être identiques ou différents et désignent chacun un groupe alkyle ou aryle C¿1~6?, ou un dérivé de ce composé, ainsi qu'un procédé destiné à la préparation de ce composé. L'invention concerne également un procédé permettant de préparer de l'imipenem représenté par la formule générale (I) à partir du composé représenté par la formule générale (II).

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