A novel chemokine expressed in inflamed adenoid, its...

C - Chemistry – Metallurgy – 12 – N

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Details

C12N 15/19 (2006.01) A61K 38/19 (2006.01) C07H 21/00 (2006.01) C07K 14/52 (2006.01) C07K 16/24 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2207262

The present invention provides nucleotide and amino acid sequences that identify and encode a novel expressed chemokine (ADEC) from inflamed adenoid tissue. The present invention also provides for antisense molecules to the nucleotide sequences which encode ADEC, expression vectors for the production of purified ADEC, antibodies capable of binding specifically to ADEC, hybridization probes or oligonucleotides for the detection of ADEC-encoding nucleotide sequences, genetically enginered host cells for the expression of ADEC, diagnostic tests for inflammation or disease based on ADEC-encoding nucleic acid molecules or antibodies capable of binding specifically to ADEC.

Des séquences de nucléotides et d'acides aminés permettent d'identifier et de coder une chimiokine récemment exprimée (ADEC) à partir de tissus adénoïdes enflammés. On décrit aussi des molécules antisens par rapport aux séquences nucléotidiques qui codent l'ADEC, des vecteurs d'expression permettant de produire de l'ADEC purifiée, des anticorps pouvant se lier spécifiquement à l'ADEC, des sondes ou des oligonucléotides d'hybridation permettant de détecter des séquences nucléotidiques codant l'ADEC, des cellules hôtes obtenues par génie génétique pour exprimer l'ADEC, et des examens diagnostiques concernant des inflammations ou maladies basés sur des molécules d'acide nucléique codant l'ADEC ou sur des anticorps pouvant se lier spécifiquement à l'ADEC.

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