C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 19/00 (2006.01) A61K 38/17 (2006.01) A61K 39/42 (2006.01) A61P 31/18 (2006.01) C07K 14/705 (2006.01) C07K 14/715 (2006.01) C07K 14/73 (2006.01) C07K 16/10 (2006.01) C07K 16/28 (2006.01) C07K 16/42 (2006.01) C07K 16/46 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) C12N 15/62 (2006.01) C12P 21/00 (2006.01)
Patent
CA 2361292
This invention relates to bispecific fusion proteins effective in viral neutralization. More specifically, such proteins have two different binding domains, an inducing-binding domain and an induced-binding domain, functionally linked by a peptide linker. Such proteins, nucleic acid molecules encoding them, and their production and use in preventing or treating viral infections are provided. One prototypical bispecific fusion protein is sCD4- SCFv(17b), in which a soluble CD4 fragment (containing domains D1 and D2) is fused to a single chain Fv portion of antibody 17b via a linker.
L'invention concerne des protéines de fusion bispécifiques efficaces dans une neutralisation virale. Plus spécifiquement, ces protéines possèdent deux domaines de liaison différents, à savoir un domaine de liaison d'induction et un domaine de liaison induit, fonctionnellement reliés par un liant de peptides. L'invention concerne également lesdites protéines, les acides nucléiques codant pour celles-ci, leur production et leur utilisation pour prévenir et traiter des infections virales. sCD4-SCFv(17b) est une protéine de fusion prototypique bispécifique, dans laquelle un fragment soluble de CD4 (contenant les domaines D1 et D2) est fusionné avec une partie de Fv à chaîne unique de l'anticorps 17b via un liant.
Berger Edward A.
Del Castillo Christie M.
Smart & Biggar
The National Institutes The Government Of The United States Of America As Represented By
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