C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) C07D 339/06 (2006.01) C07D 339/08 (2006.01) C07D 409/10 (2006.01)
Patent
CA 2206219
A multistep process for producing 8-chloro-6-(2- fluorophenyl)-1-methyl-4-H-imidazo[1,5a][1,4] benzodiazepine (midazolam) comprises treating a compound of Formula II with a lower alkyl dithiol to produce a compound of Formula III, wherein n = 2 or 3, converting the compound of Formula III to a compound of Formula VII, and then treating the compound of Formula VII with a deprotecting agent, thereby producing midazolam. Novel intermediate compounds are also disclosed.
Procédé à étages multiples pour l'obtention de la 8-chloro-6-(2- fluorophényl)-1-méthyl-4-H-imidazo[1,5a][1,4]benzodiazépine (midazolam), consistant à traiter un composé de formule II avec un dithiol d'alkyle inférieur pour l'obtention d'un composé de formule III, où n = 2 ou 3, à convertir le composé de formule III en un composé de formule VII, puis à traiter le composé de formule VII avec un agent déprotecteur, ce qui donne le midazolam. Nouveaux intermédiaires.
Khanduri Chandrahas
Khanna Jag Mohan
Kumar Naresh
Sathyanarayan Swargam
Sharma Mukesh Kumar
Fetherstonhaugh & Co.
Ranbaxy Laboratories Limited
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