A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/16 (2006.01) A61P 31/04 (2006.01) A61P 35/00 (2006.01) C07K 14/265 (2006.01)
Patent
CA 2572984
The invention relates to a composition that can inhibit the growth of tumour cells of different histological origins and activated endothelial cells. The components of said composition are polypeptide fragments of serralysins, corresponding to the C-terminal fragment, from the internal methionine of the sequence to the end of the molecule, which can be combined with one another and, optionally, with prodigiosins which potentiate the anti-tumour effect of the composition. The prodigiosins in the composition can be at a concentration of between 0.1 - 100 nM. The anti-proliferative action of the composition is provided by apoptotic mechanisms. The in vivo administration of the inventive composition has an anti-tumour effect, an anti-angiogenic effect and protects against malignant tumours.
La présente invention concerne une composition capable d'inhiber la croissance de cellules tumorales de différentes origines histologiques et de cellules endothéliales activées. Cette composition renferme des fragments polypeptidiques de serralysines, correspondant au fragment C-terminal, à partir de la méthionine interne de la séquence jusqu'à la fin de la molécule, ces fragments pouvant être combinés entre eux et éventuellement avec des prodigiosines qui augmentent l'effet antitumoral de la composition. La composition peut renfermer 0,1 - 100 nM de prodigiosines. L'action anti-proliférante de la composition est induite par des mécanismes d'apoptose. L'administration in vivo de la composition a un effet antitumoral, anti-angiogénique et protecteur contre les tumeurs malignes.
Abrahantes Perez Maria Del Carmen
Bequet Romero Monica
Castellanos Serra Lila Rosa
Garcia Suarez Jose
Gasmuri Gonzalez Caridad Anais
Centro de Ingenieria Genetica Y. Biotecnologia
Deeth Williams Wall Llp
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