A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/40 (2006.01) A61K 31/4015 (2006.01) C07D 207/26 (2006.01)
Patent
CA 2187086
A pharmaceutical composition for therapeutically treating tardive dyskinesia, which comprises a compound having an enzyme-inhibitory activity against a phospho- diesterase as the active ingredient, is now provided. Rolipram is preferred as the active ingredient. When rolipram is administered to such rats as experimental model, which have tardive dyskinesia induced by consecu- tive administrations of haloperidol, there can be obtained such curative effect that the symptoms of tardive dyskinesia are suppressed dose-dependently.
Composition médicinale destinée à traiter la dyskinésie tardive, contenant un composé ayant une activité inhibitrice de la phosphodiestérase en tant qu'ingrédient actif et dont un exemple préféré est le rolipram. Lorsque ledit composé est administré à des rats d'expérimentation atteints de dyskinésie tardive induite par l'administration chronique d'halopéridol, il présente un effet thérapeutique de suppression du symptôme de dyskinésie tardive selon la dose.
Hashimoto Kenji
Inada Toshiya
Iyo Masaomi
Kitao Yoshie
Maeda Yohko
Iyo Masaomi
Macrae & Co.
Meiji Seika Kaisha Ltd.
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