C - Chemistry – Metallurgy – 08 – G
Patent
C - Chemistry, Metallurgy
08
G
C08G 69/00 (2006.01) C08G 69/48 (2006.01) C07K 1/00 (2006.01)
Patent
CA 2656077
The invention relates to an improved process for the preparation of poly-.alpha.-glutamic acids which comprises the polymerisation of tertiary .gamma.-esters of .alpha.-glutamic acid N-carboxy anhydride with appropriate solvents and initiators, followed by acid hydrolysis of the resulting poly-.alpha.-glutamic acid-.gamma.-ester. The process is particularly advantageous in that it allows to carefully control the molecular weight of the resulting poly-.alpha.-glutamic acid. The invention also relates to poly-.alpha.-glutamic acids capped at the amino terminus with carboxylic acids or amino acids and to a process for the preparation thereof.
L'invention concerne un procédé amélioré pour la préparation d'acides poly-.alpha.-glutamiques, comprenant la polymérisation de .gamma.-esters tertiaires d'acide .alpha.-glutamique N-carboxy anhydride avec des solvants et des initiateurs appropriés, suivie d'une hydrolyse acide du .gamma.-ester de l'acide poly-.alpha.-glutamique résultant. Le procédé est particulièrement avantageux par le fait qu'il permet un contrôle soigneux de la masse moléculaire de l'acide poly-.alpha.-glutamique résultant. L'invention concerne également des acides poly-.alpha.-glutamiques coiffés à l'extrémité terminale amino par des acides carboxyliques ou des acides aminés, ainsi qu'un procédé permettant de les préparer.
Artico Marco
Da Re Giovanni
Feliciotti Luca
Grugni Mario
Mckennon Marc
Cell Therapeutics Inc.
Cell Therapeutics Inc.- Sede Secondaria
Kirby Eades Gale Baker
LandOfFree
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