A regioselective metal catalyzed synthesis of annelated...

C - Chemistry – Metallurgy – 07 – D

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C07D 471/04 (2006.01) C07D 471/14 (2006.01) C07D 487/04 (2006.01) C07D 491/14 (2006.01)

Patent

CA 2693142

A regioselective metal catalyzed synthesis of benzimidazoles and azabenzimidazoles The present invention relates to a process for the regioselective synthesis of compounds of the formula (I), wherein R1; R2; R3; R4; J1; J2; J3; J4 and G have the meanings indicated in the claims. The present invention provides a direct metal, e.g. palladium or copper, catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N--substituted benzimidazoles or azabenzimidazoles of formula (I) starting from 2-halo- nitroarenes and N-substituted amides useful for the production of pharmaceuticals, diagnostic agents, liquid crystals, polymers, herbicides, fungicidals, nematicidals, parasiticides,

L'invention porte sur une synthèse régiosélective catalysée par un métal de benzimidazoles et d'azabenzimidazoles. L'invention concerne un procédé de synthèse régiosélective de composés de la formule I, dans laquelle R1; R2; R3; R4; J1; J2; J3; J4 et G sont tels que spécifiés dans les revendications. L'invention se rapporte à un procédé régiosélectif direct catalysé par un métal, p.ex. le palladium ou le cuivre, qui permet de préparer une large variété de benzimidazoles ou azabenzimidazoles multifonctionnels asymétriques N-substitués de la formule I à partir de 2-halo-nitroarènes et d'amides N-substitués, qui sont destinés à la production de produits pharmaceutiques, d'agents diagnostiques, de cristaux liquides, de polymères, d'herbicides, de fongicides, de nématicides, de parasiticides, d'insecticides, d'acaricides et d'arthropodicides.

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