C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/52 (2006.01) C07H 21/04 (2006.01) C12N 1/20 (2006.01) C12N 9/00 (2006.01) C12N 15/72 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2067991
A THERMOSTABLE LIGASE MEDIATED DNA AMPLIFICATION SYSTEM FOR THE DETECTION OF GENETIC DISEASES ABSTRACT OF THE DISCLOSURE: The present invention relates to the cloning of the gene of a thermophilic DNA ligase, from Thermus aquaticus strain HB8, and the use of this ligase for the detection of specific sequences of nucleotides in a variety of nucleic acid samples, and more particularly in those samples containing a DNA sequence characterized by a difference in the nucleic acid sequence from a standard sequence including single nucleic acid base pair changes, deletions, insertions or translocations.
Barany Francis
Hood Leroy
Kaiser Robert J. Jr.
Nickerson Deborah A.
Zebala John
California Institute Of Technology
Cornell Research Foundation Inc.
Goudreau Gage Dubuc
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