Acetic acid as contrast agent in fluorescence spectroscopy

Details Acetic acid as contrast agent in fluorescence spectroscopy Acetic acid as contrast agent in fluorescence spectroscopy

A - Human Necessities

61

K

A61K 49/00 (2006.01) A61B 5/00 (2006.01) A61B 6/00 (2006.01) G01N 21/64 (2006.01) G01N 33/52 (2006.01) G01N 33/72 (2006.01)

Patent

CA 2306795

A method for using acetic acid as a signal enhancing contrast agent during fluorescence spectroscopy of normal and neoplastic tissue, particularly epithelium. In one aspect, the invention includes a method of detecting tissue abnormality in a diagnostic tissue sample in a patient, comprising the steps of obtaining a first fluorescence intensity spectrum from the diagnostic tissue sample; thereafter, applying acetic acid to the diagnostic tissue sample in sufficient concentration to alter the response of such diagnostic tissue sample to electromagnetic radiation for at least an effective period of time; during the effective period of time, obtaining a second fluorescence intensity spectrum from the diagnostic tissue sample; determining a parameter indicative of a change between the first and second fluorescence emission intensity spectra; and analyzing the deterimined parameter to determine a probability that the diagnostic tissue sample is normal or abnormal.

L'invention concerne un procédé qui consiste à utiliser l'acide acétique comme agent de contraste rehausseur de signal en spectroscopie fluorescente de tissu normal et néoplasique, en particulier l'épithélium. Selon un aspect, l'invention concerne un procédé permettant de déceler une anomalie tissulaire dans un échantillon de tissu prélevé chez un patient aux fins de diagnostic, qui comprend les étapes suivantes : obtention d'un premier spectre d'intensité de fluorescence sur l'échantillon considéré; application d'acide acétique sur ledit échantillon en concentration suffisante pour modifier la réponse de cet échantillon au rayonnement électromagnétique, pendant au moins une période de temps efficace; durant cette période, obtention d'un second spectre d'intensité de fluorescence sur le même échantillon; détermination d'un paramètre indiquant un changement entre les premier et second spectre susmentionnés; et analyse du paramètre ainsi déterminé pour évaluer une probabilité de configuration normale ou d'anomalie dans l'échantillon étudié.

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