Acid-cleavable compound

Details Acid-cleavable compound Acid-cleavable compound

A - Human Necessities

61

K

167/129, 167/139

A61K 39/395 (2006.01) C07D 207/452 (2006.01) C07D 405/12 (2006.01)

Patent

CA 1241949

Abstract of the Disclosure Amino-sulfhydryl cross-linking reagents that are cleavable under mildly acidic conditions are disclosed. Also disclosed are methods of making the cross-linkers, as well as methods of using the cross-linkers, e.g , to deliver a biologically active substance across the membranes of selected cells in a heterogeneous cell population; once inside the cell the active substance is released, intact, by the transient, mild acidity of certain cell structures. Finally, a method of characterizing complex multi-chain protein structures is disclosed.

484287

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