Acridine and quinoline dervatives as sirtuin modulators

Details Acridine and quinoline dervatives as sirtuin modulators Acridine and quinoline dervatives as sirtuin modulators

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/435 (2006.01) C07D 215/48 (2006.01) C07D 215/52 (2006.01) C07D 219/04 (2006.01) C07D 219/10 (2006.01) C07D 401/14 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01) C07D 409/04 (2006.01) C07D 409/14 (2006.01) C07D 413/04 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2599992

Provided herein are sirtuin-modulating compounds which are derivatives of guioline or acridine and methods of use thereof . The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, chemo therapeutic induced neuropathy, neuropathy associated with an ischemic event, polyglutamine diseases, ocular diseases and/or disorders, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

L'invention concerne de nouveaux composés modulateurs de la sirtuine et leurs procédés d'utilisation. Les composés modulateurs de la sirtuine peuvent être utilisés pour augmenter la durée de vie d'une cellule et pour traiter et/ou empêcher une variété étendue de maladies ou affections, y compris les maladies ou affections associées au vieillissement ou au stress, les diabètes, l'obésité, les maladies neurodégénératives, la neuropathie induite par la chimiothérapie, la neuropathie associée à un événement ischémique, les maladies à expansion de polyglutamine, les maladies et/ou affections oculaires, les maladies cardiovasculaires, les affections de la coagulation sanguine, les inflammations, le cancer et/ou les bouffées congestives. L'invention concerne également des compositions renfermant un composé modulateur de la sirtuine en combinaison avec un autre agent thérapeutique.

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