Active drug delivery in the gastrointestinal tract

Details Active drug delivery in the gastrointestinal tract Active drug delivery in the gastrointestinal tract

A - Human Necessities

61

K

A61K 9/22 (2006.01)

Patent

CA 2562741

Apparatus (30) for drug administration is provided, including an ingestible capsule (32), which includes a drug (36), stored by the capsule (32), and an environmentally-sensitive mechanism (18), adapted to change a state thereof responsively to a disposition of the capsule (32) within a gastrointestinal (GI) tract (50) of a subject. The capsule (32) further includes first and second electrodes (16), and a control component (14), adapted to facilitate passage of the drug (36), in response to a change of state of the environmentally-sensitive mechanism (18), through an epithelial layer of the GI tract (50) by driving the first and second electrodes (16) to apply a series of pulses at a current of less than about 10 mA, at a frequency of between about 12 Hz and about 24 Hz, and with a pulse duration of between about 0.5 milliseconds and about 3 milliseconds. Other embodiments are also described.

L'invention concerne un appareil (30) permettant d'administrer un médicament, qui comprend une capsule (32) pouvant être ingérée renfermant le médicament (36), stocké par ladite capsule (32), et un mécanisme sensible à l'environnement (18) conçu pour modifier un état de cet environnement en réponse à une disposition de ladite capsule (32) dans le tractus gastro-intestinal (GI) (50) d'un sujet. Cette capsule (32) comprend également une première et une seconde électrode (16) et un composant de commande (14) conçu pour faciliter le passage du médicament (36) en réponse à un changement d'état du mécanisme sensible à l'environnement (18), via une couche épithéliale du tractus GI (50) par entraînement de la première et de la seconde électrode (16) à appliquer une série d'impulsions à un courant inférieur à environ 10 mA, à une fréquence comprise entre environ 12 Hz et 24 Hz et pendant une durée d'impulsion comprise entre environ 0,5 millisecondes et 3 millisecondes. L'invention concerne également d'autres modes de réalisation.

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