Acylated nonadepsipeptides used as lysobactin derivatives

Details Acylated nonadepsipeptides used as lysobactin derivatives Acylated nonadepsipeptides used as lysobactin derivatives

C - Chemistry, Metallurgy

07

K

C07K 11/02 (2006.01) A61P 31/04 (2006.01) C07K 5/06 (2006.01)

Patent

CA 2586704

The invention relates to nonadepsipeptides (lysobactin derivatives), methods for the production thereof, and the use thereof for producing medicaments used for treating and/or preventing diseases, especially bacterial infectious diseases. Said novel lysobactin derivatives distinguish themselves from the natural substance by the N-terminal peptide chain which comprises a 3-(3- pyridyl)-alanyl radical.

L'invention concerne de nouveaux nonadepsipeptides (dérivés de lysobactine), leurs procédés de production ainsi que leur utilisation pour produire des médicaments servant au traitement et/ou à la prophylaxie de maladies, notamment de maladies infectieuses bactériennes. Les nouveaux dérivés de lysobactine se distinguent de la substance naturelle par la chaîne peptidique N-terminale qui contient un radical 3-(3-pyridyl)-alanyle.

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