C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 251/86 (2006.01)
Patent
CA 2542106
The invention relates to acylhydrazone derivatives of formula (I), which are SGK inhibitors and can be used for the treatment of diseases and afflictions associated with SGK, such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systematic and pulmonary hypertension, cardiovascular diseases and kidney diseases and in general for all types of fibroses and inflammatory processes. In said formula: R1 and R5 independently of one another represent H, OH, OA, OAc or methyl; R2, R3, R4, R6, R7, R8, R9 and R10 independently of one another represent H, OH, OA, OAc, OCF3, Hal, NO2, CF3, A, CN, OSO2CH3, SO2CH3, NH2, or COOH; R11 represents H or CH3; A represents an alkyl comprising 1, 2, 3, or 4 C atoms; X represents CH2, CH2CH2, OCH2 or - CH(OH)- and Hal represents F, Cl, Br or I.
L'invention concerne de nouveaux dérivés d'acylhydrazone de formule (I). Ces composés sont des inhibiteurs de la kinase SGK et peuvent servir à traiter des maladies et pathologies liées à la kinase SGK telles que le diabète, l'obésité, un syndrome métabolique (dyslipidémie), une hypertonie systémique et pulmonaire, des maladies cardiovasculaires ainsi que des maladies rénales et, de manière générale, toute forme de fibrose et processus inflammatoire. Dans ladite formule (I) : R?1¿, R?5¿ désignent indépendamment l'un de l'autre H, OH, OA, OAc ou un groupe méthyle ; R?2¿, R?3¿, R?4¿, R?6¿, R?7¿, R?8¿, R?9¿, R?10¿ représentent indépendamment les uns des autres H, OH, OA, OAc, OCF¿3?, Hal,¿?NO¿2?, CF¿3?, A, CN, OSO¿2?CH¿3?, SO¿2?CH¿3?, NH¿2? ou COOH ; R?11¿ désigne H ou CH¿3 ?; A représente un groupe alkyle comportant 1, 2, 3 ou 4 atome(s) de carbone ; X désigne CH¿2?, CH¿2?CH¿2?, OCH¿2? ou -CH(OH)- ; Hal représente F, Cl, Br ou I.
Beier Norbert
Burgdorf Lars
Drosdat Helga
Gericke Rolf
Lang Florian
Fetherstonhaugh & Co.
Merck Patent Gesellschaft Mit Beschraenkter Haftung
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