A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61P 9/10 (2006.01) C07K 14/52 (2006.01) C12N 15/00 (2006.01) C12N 15/864 (2006.01)
Patent
CA 2419245
The use of recombinant adeno-associated virus (rAAV) virions for delivery of genes encoding angiogenic factors to muscle tissue is disclosed. The invention describes such methods of delivery and also describes methods for treating an ischemic condition such as myocardial ischemia. The methods include direct delivery of rAAV virions to a muscle via intramuscular injection and indirect delivery to a muscle via an injection into a blood vessel supplying blood to the muscle. The invention provides for sustained expression of the rAAV virion- delivered angiogenic factor gene or genes, which subsequently leads to a quantifiable therapeutic angiogenic factor gene or genes, which subsequently leads to a quantifiable therapeutic effect, namely an increase in new blood vessel formation resulting in an increase in blood flow to the ischemic muscle tissue.
L'invention concerne l'utilisation de virions de virus associé aux adénovirus (rAAV) pour la distribution au tissu musculaire de gènes codant les facteurs angiogéniques. On décrit des procédés relatifs à cette distribution et des procédés relatifs au traitement d'un état ischémique du type ischémie myocardique. Les procédés consistent à administrer directement les virions rAAV au tissu musculaire par injection intramusculaire et indirectement par injection dans un vaisseau sanguin qui alimente le muscle considéré. L'invention concerne en outre l'expression prolongée de gène(s) de facteur angiogénique à distribution par virions rAAV, donnant un effet thérapeutique quantifiable qui se traduit par l'augmentation de la formation de nouveaux vaisseaux sanguins et donc par une augmentation du flux sanguin vers le tissu musculaire ischémique.
Ikeda Uichi
Maeda Yoshikazu
Ozawa Keiya
Shimada Kazuyuki
Shimpo Masahisa
Ikeda Uichi
Maeda Yoshikazu
Ozawa Keiya
Shimada Kazuyuki
Shimpo Masahisa
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