Adjuvanting material

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/39 (2006.01) A61P 37/04 (2006.01)

Patent

CA 2596730

The present invention provides an adjuvanting material, the adjuvanting material comprising a lipid dendritic cell targeting moiety to which is covalently linked a metal chelating group. Further, the present invention provides an immunogenic composition comprising (a) a lipid dendritic cell targeting moiety to which is covalently linked a metal chelating group; (b) an antigen comprising a metal affinity tag; and optionally (c) metal ions, whereby the antigen is linked to the lipid dendritic cell targeting moiety via the interaction between the metal affinity tag and the metal chelating group.

La présente invention concerne un matériau adjuvant comprenant un groupement lipidique ciblant une cellule dendritique, liée de façon covalente à un groupement métallique chélatant. En outre, la présente invention concerne une préparation immunogène comprenant (a) un groupement lipidique ciblant une cellule dendritique liée de façon covalente à un groupement métallique chélatant ; (b) un antigène comprenant une zone d'affinité avec un métal ; et éventuellement (c) des ions métalliques, l'antigène étant lié au groupement lipidique ciblant une cellule dendritique par le biais de l'interaction entre la zone d'affinité avec un métal et le groupement métallique chélatant.

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