Aerothricin analogs, their preparation and use

Details Aerothricin analogs, their preparation and use Aerothricin analogs, their preparation and use

C - Chemistry, Metallurgy

07

K

C07K 7/56 (2006.01) A61K 38/10 (2006.01) A61K 38/12 (2006.01) C07K 7/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2335394

The present invention relates to novel Aerothricins represented by Formula (I), wherein R1, R2, R3, R4, R5, X, Y, Z, and m are as defined in Claim 1; and pharmaceutically acceptable salts thereof. The present invention also relates to a pharmaceutical composition comprising an Aerothricin of Formula (I) and a pharmaceutically acceptable carrier. Furthermore, the present invention relates to the use of such Aerothricins for the preparation of medicaments, as well as to processes and intermediates for the preparation of the Aerothricins of Formula (I).

Cette invention a trait à de nouvelles aérothricines correspondant à la formule (I), formule dans laquelle R<1>, R<2>, R<3>, R<4>, R<5>, X, Y, Z et m sont tels que définis dans la première revendication, ainsi qu'à leurs sels acceptables du point de vue pharmaceutique. L'invention concerne également une aérothricine correspondant à la formule (I) et son excipient acceptable du point de vue pharmaceutique. Elle porte, de surcroît, sur l'utilisation de ces aérothricines pour fabriquer des médicaments ainsi que sur des procédés de fabrication desdites aérothricines et sur leurs intermédiaires entrant dans cette fabrication.

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