Agents and methods for enhancement of transdermal transport

Details Agents and methods for enhancement of transdermal transport Agents and methods for enhancement of transdermal transport

A - Human Necessities

61

B

A61B 17/20 (2006.01) A61B 5/00 (2006.01)

Patent

CA 2598751

The invention according to an exemplary embodiment relates to a method for transporting a substance across a biological membrane comprising the steps of applying a delipidation agent to a portion of the biological membrane, applying a hydration agent to the portion of the biological membrane, sonicating the portion of the biological membrane, and transporting the substance across the biological membrane. The step of applying the delipidation agent may be carried out prior to or simultaneously with the step of applying the hydration agent. The hydration agent may be applied before, during, or after the sonication step. The methods according to exemplary embodiments of the invention can provide improved transdermal transport in applications such as continuous analyte extraction and analysis and transdermal delivery of drugs and vaccines.

Dans un exemple de mode de réalisation, la présente invention concerne un procédé pour transporter une substance à travers une membrane biologique, le procédé comprenant l'application d'un agent de délipidation, à une partie de la membrane biologique, l'application d'un agent d'hydratation à la partie de la membrane biologique, la sonification de la partie de la membrane biologique, et le transport de la substance à travers la membrane biologique. L'étape d'application de l'agent de délipidation peut être mise en oeuvre avant ou en même temps que l'étape d'application de l'agent d'hydratation. L'agent d'hydratation peut être appliqué avant, pendant ou après l'étape de sonification. Les procédés, selon les exemples de mode de réalisation de l'invention, permettent d'obtenir un transport transdermique amélioré dans des applications telles que l'extraction et l'analyse d'analyte en continu, et l'administration transdermique d'agents pharmaceutiques et de vaccins.

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