Aldehyde derivatives

Details Aldehyde derivatives Aldehyde derivatives

C - Chemistry, Metallurgy

07

D

C07D 211/60 (2006.01) C07C 215/08 (2006.01) C07C 215/28 (2006.01) C07C 217/34 (2006.01) C07C 217/64 (2006.01) C07C 229/36 (2006.01) C07C 233/76 (2006.01) C07C 271/12 (2006.01) C07C 271/22 (2006.01) C07C 271/28 (2006.01) C07C 271/30 (2006.01) C07C 323/41 (2006.01) C07C 323/60 (2006.01) C07C 333/08 (2006.01) C07D 205/04 (2006.01) C07D 207/16 (2006.01) C07D 209/14 (2006.01) C07D 209/20 (2006.01) C07D 211/62 (2006.01) C07D 307/68 (2006.01) C07D 333/18 (2006.01) C07D 401/02 (2006.01) C07D 401/06 (2006.01) C07D 4

Patent

CA 2071621

Aldehyde derivatives with a specific calpain inhibiting activity and a platelet-aggregation inhibiting effect with formula (I) or formula (II): Image (I) wherein R1 represents an aromatic hydrocarbon group, a heterocyclic group, or a group of -X-R3 in which X represents O, -S(O)m- (m = 0, 1, or 2), and R3 represents an aromatic hydrocarbon group, a heterocyclic group, or an alkyl group; Z represents R4-Y- or R6O-CH(R5)- in which Y represents a 3- to 7-membered nitrogen-containing saturated heterocyclic group, or a single cyclic saturated hydrocarbon group, R4 represents an alkyl group, an alkenyl group, an alkynyl group, an acyl group, a sulfonyl group, an alkoxycarbonyl group, a carbamoyl group, or a thiocarbamoyl group, R5 represents hydrogen, an alkyl group, or an aromatic hydrocarbon group, and R6 represents an acyl group, a carbamoyl group, a thiocarbamoyl group, or an alkyl group; and n is an integer of 1 to 5. Image (II) wherein R7, R8, R9, and R10 are defined in the specification. - 287-

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