Alkylene-diamine derivatives and process for preparing same

Details Alkylene-diamine derivatives and process for preparing same Alkylene-diamine derivatives and process for preparing same

C - Chemistry, Metallurgy

07

C

260/380, 260/542

C07C 271/20 (2006.01) C07C 291/04 (2006.01) C07D 203/12 (2006.01) C07D 203/14 (2006.01) C07D 209/48 (2006.01) C07D 265/30 (2006.01) C07D 295/13 (2006.01)

Patent

CA 1181755

ABSTRACT OF THE DISCLOSURE New alkylenediamine derivatives of the general formula Image (I) wherein Rl and R2 each represent halogen or a lower alkyl group, R3 stands for hydrogen, a lower alkyl group, an acyl group derived from a lower aliphatic carboxylic acid bearing optionally 1-3 halogen substituents or from an aromatic carboxylic acid, a lower alkoxycarbonyl group, or a sulfonyl group derived from a lower aliphatic sulfonic acid or an aromatic sulfonic acid, R4 and R5 each represent hydrogen or a lower alkyl group, R6 and R7 each represent hydrogen, a lower alkyl group bear- ing optionally a hydroxy or halogen substituent, an acyl group derived from a lower aliphatic carboxylic acid bearing optionally an amino or a mono- or di- (lower alkyl)-amino substituent, a lower alkoxy- carbonyl group, or a sulfonyl group derived from a lower aliphatic sulfonic acid or an aromatic sulfonic acid, or R6 and R7 may form, together with the adjacent nitrogen atom, a 3-7 membered heterocyclic group optionally contain- ing a further hetero atom, such as an oxygen, sulfur or nitrogen atom, or a group derived from a cyclic imide of a dicarboxylic acid, and n is zero or one, with the provisos that (i) if R1 and R2 each stand for methyl group, at least one of R4 and R5 must be other than hydrogen, and (ii) if R1 and R2 each stand for methyl group, R3 and R5 each stand for hydrogen, R4 represents methyl or ethyl group and n is zero, at least one of R6 and R7 must be other than ethyl group, are prepared from the appropriately substituted starting substances by methods known per se. The new compounds according to the invention have anti-arrhythmic effects and are devoid of the undesired circulatory side-effects of the known anti-arrhythmic sub- stances.

397480

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