C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 295/116 (2006.01) A61K 31/135 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/535 (2006.01) C07C 201/08 (2006.01) C07C 205/45 (2006.01) C07C 217/24 (2006.01) C07C 225/22 (2006.01) C07C 231/02 (2006.01) C07C 233/65 (2006.01) C07C 235/44 (2006.01) C07C 323/25 (2006.01) C07D 295/092 (2006.01)
Patent
CA 2257136
The present invention describes certain alkyloxyamino-substituted fluorenones which inhibit protein kinase C, as well as pharmaceutical compositions including these compounds and methods of using these compounds to control protein kinase C activity in mammals, including humans. More specifically, the present compounds are useful for the treatment of neoplastic disease states, disorders associated with abnormal blood flow (including hypertension, ischemia, atherosclerosis, coagulation disorders), and inflammatory diseases (including immune disorders, asthma, lung fibrosis, and psoriasis).
L'invention concerne certains fluorénones à substitution alkyloxyamino qui inhibent la protéine kinase C, ainsi que des compositions pharmaceutiques comprenant ces composés et des procédé d'utilisation desdits composés pour réguler l'activité de la protéine kinase C chez des mammifères dont les humains. Plus spécifiquement, lesdits composés sont utiles pour le traitement d'états pathologiques néoplasiques, de troubles associés à un débit sanguin anormal (dont l'hypertension, l'ischémie, l'athérosclérose, les troubles de la coagulation) et des affections inflammatoires (dont des troubles de l'immunité, l'asthme, la fibrose pulmonaire et le psoriasis).
Ciske Fred L.
Diekema Keith A.
Dinerstein Robert J.
Jones Winton D.
Aventisub II Inc.
Hoechst Marion Roussel Inc.
Osler Hoskin & Harcourt Llp
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