Allergen-binding ige monoclonal antibodies and method for...

Details Allergen-binding ige monoclonal antibodies and method for... Allergen-binding ige monoclonal antibodies and method for...

C - Chemistry, Metallurgy

07

K

C07K 14/46 (2006.01) A61K 39/35 (2006.01) C07K 16/16 (2006.01) C07K 16/18 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2676838

The present invention relates to human IgE antibodies and derivatives thereof, which bind non-continuous planar allergenic epitope, such as in .beta.-lactoglobulin, with high affinity and specificity. The present invention also relates to processes for making and engineering such allergen binding monoclonal antibodies and to methods for using these antibodies and derivatives thereof in the field of immunodiagnostics and immunotherapy.

La présente invention porte sur des anticorps IgE humains et sur des dérivés de ceux-ci, qui se lient à un épitope allergénique plan non continu, comme dans la .beta.-lactoglobuline, avec des affinités et une spécificité élevées. La présente invention porte également sur des procédés de fabrication et d'obtention par génie génétique de tels anticorps monoclonaux de liaison à un allergène et sur des procédés pour utiliser ces anticorps et dérivés de ceux-ci dans le domaine de l'immunodiagnostique et de l'immunothérapie.

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