C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/15 (2006.01) A61K 38/57 (2006.01) C07K 14/81 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2186908
The present invention provides an analogue of human alpha-1-antichymotrypsin where the amino acid at position 358 is selected from the group consisting of methionine, isoleucine, valine, alanine, aspartic acid, threonine, and glutamic acid. The alpha-1-antichymotrypsin analogues of the present invention are efficient inhibitors of human neutrophil elastase. The present invention also provides nucleic acide sequences encoding said analoges, expression vectors, transformed host cells, and a method of producing the analogues.
La présente invention concerne un analogue de la alpha -1-antichymotrypsine humaine où l'acide aminé en position 358 est choisi dans le groupe constitué par la méthionine, l'isoleucine, la valine, l'alanine, l'acide aspartique, la thréonine et l'acide glutamique. Les analogues de la alpha -1-antichymotrypsine de la présente invention sont d'efficaces inhibiteurs de l'élastase des granulocytes neutrophiles humains. La présente invention concerne également des séquences d'acides nucléiques codant pour lesdits analogues, des vecteurs d'expression, des cellules hôtes transformées et une méthode pour produire les analogues.
Cooperman Barry S.
Rubin Harvey
Schechter Norman
Wang Zhi Mei
Borden Ladner Gervais Llp
The Trustees Of The University Of Pennsylvania
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