Alpha 5 - beta 1 antibodies and their uses

Details Alpha 5 - beta 1 antibodies and their uses Alpha 5 - beta 1 antibodies and their uses

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2714071

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin .alpha.5.beta.1 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies or antigen binding portions thereof are also provided. The disclosure also provides methods for treating various cancers using the anti-.alpha.5.beta.1 antibodies or antigen binding portions thereof described herein.

Cette invention concerne des anticorps monoclonaux isolés, en particulier des anticorps monoclonaux humains, ou des portions de liaison antigénique de ces anticorps, qui se fixent spécifiquement à lintégrine a5ß1 avec une forte affinité. Linvention concerne également des molécules dacides nucléiques codant ces anticorps, des vecteurs dexpression, des cellules hôtes et des procédés dexpression de ces anticorps. Linvention concerne par ailleurs des immunoconjugués, des molécules bispécifiques et des compositions pharmaceutiques comprenant ces anticorps ou les portions de liaison antigénique de ces anticorps. Linvention concerne aussi des procédés de traitement de différents cancers utilisant les anticorps anti-a5ßl ou les portions de liaison antigénique de ces anticorps.

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