C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
167/246, 260/518
C07C 403/20 (2006.01) A61K 31/16 (2006.01) A61K 31/19 (2006.01) A61K 31/20 (2006.01) A61K 31/215 (2006.01) A61K 31/23 (2006.01)
Patent
CA 1278308
ABSTRACT OF THE DISCLOSURE Polyolefinic compounds, useful in the treatment of psoriasis, are disclosed. The compounds are represented by the general formula Image in which R and R1 are each hydrogen or an alkyl group of from 1 to 5 carbon atoms; R2 is an alkyl group of from 1 to 5 carbon atoms; R3 is hydroxyl, alkoxy of from 1 to 5 carbon atoms, NH2,NHR2 or NR2R2 and Z is a cycloalkyl, cycloalkenyl or cycloalkdienyl group substituted with from 0 to 5 alkyl groups, a keto group or a hydroxyl group or a phenyl group substituted with from 0 to 4 hydroxy, alkoxy, alkyl or trifluoromethyl groups or halogen atoms or combinations thereof and the pharmaceutically-acceptable salts thereof. The foregoing compounds have been found to be effective in the treatment of psoriasis.
431328
Chan Wan-Kit
Jones Howard
Loev Bernard
Chan Wan-Kit
Jones Howard
Loev Bernard
Mcfadden Fincham
Usv Pharmaceutical Corporation
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