.alpha.,.alpha.-disubstituted aromatics and heteroaromatics...

Details .alpha.,.alpha.-disubstituted aromatics and heteroaromatics... .alpha.,.alpha.-disubstituted aromatics and heteroaromatics...

C - Chemistry, Metallurgy

07

D

260/200, 167/211

C07D 213/04 (2006.01) C07D 213/16 (2006.01) C07D 213/26 (2006.01) C07D 213/30 (2006.01) C07D 213/32 (2006.01) C07D 213/38 (2006.01) C07D 213/40 (2006.01) C07D 213/50 (2006.01) C07D 213/53 (2006.01) C07D 213/57 (2006.01) C07D 239/26 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/06 (2006.01) C07D 405/14 (2006.01) C07D 409/06 (2006.01) C07D 409/14 (2006.01) C07D 471/04 (2006.01)

Patent

CA 1339127

Cognitive defeciencies or neurological dysfunction in mammals are treated with .alpha., .alpha.-disubstituted aromatic or heteroaromatic compounds. The compounds have the formula: (See Fig. I) or a salt thereof wherein X and Y are taken together to form a saturated or unsaturated carbocyclic or heterocyclic first ring and the shown carbon in said ring is .alpha. to at least one additional aramatic ring or heteroaromatic ring fused to the first ring; one of Het1 or Het2 is 2, 3, or 4-pyridyl or 2, 4, or 5-pyrimidinyl and the other is selected fran (a) 2, 3, or 4-pyridyl, (b) 2, 4, or 5-pyrimidinyl, (c) 2-pyrazinyl, (d) 3, or 4-pyridazinyl, (e) 3, or 4-pyrazolyl, (f) 2, or 3-tetrahydrofuranyl, and (g) 3-thienyl.

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