.alpha.-chain-modified isocarbacyclins and process for the...

Details .alpha.-chain-modified isocarbacyclins and process for the... .alpha.-chain-modified isocarbacyclins and process for the...

C - Chemistry, Metallurgy

07

C

C07C 405/00 (2006.01) C07C 65/19 (2006.01) C07C 69/76 (2006.01) C07D 307/20 (2006.01) C07D 309/12 (2006.01) C07D 333/38 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2146361

Provided are .alpha.-chain-modified isocarbacyclins of which the .alpha.-chain is modified with a phenylene group, a cycloalkylene group or a thiophendiyl group, and these .alpha.-chain-modified isocarbacyclins show the activity for inhibiting the DNA synthesis of human smooth muscle cell and are expected to be capable of inhibiting the hypertrophy of a blood vessel.

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