C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/16 (2006.01) A61P 21/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/435 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2361138
The invention relates to relatively short peptides (termed .alpha.-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds. The .alpha.-conotoxins, as described herein, are useful for as neuromuscular blocking agents, such as muscle relaxants.
L'invention concerne des peptides relativement courts, (dénommés ici .alpha.-conotoxines), dont la longueur est d'environ 10 à 25 restes, disponibles naturellement en quantités infimes dans le venin des escargots marin (cônes), ou des analogues de ces peptides, lesquels comprennent préférablement deux liaisons disulfure. Les .alpha.-conotoxines décrites dans l'invention sont utiles en tant qu'agents de blocage neuromusculaire, tels que des myorelaxants.
Hillyard David R.
Jones Robert M.
Layer Richard T.
Mcintosh J. Michael
Olivera Baldomero M.
Cognetix Inc.
Gowling Lafleur Henderson Llp
University Of Utah Research Foundation
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