Alpha-substituted heteroarylalkyl phosphonate derivatives

Details Alpha-substituted heteroarylalkyl phosphonate derivatives Alpha-substituted heteroarylalkyl phosphonate derivatives

C - Chemistry, Metallurgy

07

F

C07F 9/58 (2006.01) A61K 31/22 (2006.01) A61K 31/366 (2006.01) A61K 31/40 (2006.01) A61K 31/405 (2006.01) A61K 31/44 (2006.01) A61K 31/66 (2006.01) A61K 31/675 (2006.01) C07F 9/6509 (2006.01) C07F 9/6539 (2006.01)

Patent

CA 2475882

The present invention relates to novel .alpha.-substituted heteroarylalkylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and very low density lipoproteins) and for lowering plasma levels of total cholesterol.

L'invention porte sur des dérivés alpha-substitués d'hétéroarylalkyl phosphonate et leurs utilisations pour abaisser la concentration plasmique en lipoprotéines apo (a), Lp(a), apo B, et associées à apo B (lipoprotéines à basse densité et très basse densité), et abaisser la concentration plasmique en cholestérol total.

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