A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/43 (2006.01) A61K 31/7105 (2006.01) A61K 49/00 (2006.01) A61P 35/00 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2740310
The present invention relates to a method for diagnosis and/or prognosis of cancer and for monitoring the progression of cancer and/or the therapeutic efficacy of an anti-cancer treatment in a subject by determining the molecular form of cadherin at the cell surface of cancer cells in the subject. The invention also relates to a method for preventing, inhibiting or treating cancer or its metastasis in a subject by increasing the adhesive forms of cadherin and/or decreasing the non-adhesive forms of cadherin at the cell surface. The invention also relates to a method step of determining the expression level of furin and proprotein convertase 5A (PC5A).
La présente invention concerne un procédé de diagnostic et/ou de pronostic du cancer, et de surveillance de la progression du cancer et/ou de l'efficacité thérapeutique d'un traitement anti-cancéreux chez un sujet. Ledit procédé consiste à déterminer la forme moléculaire de la cadhérine sur la surface cellulaire des cellules cancéreuses dudit sujet. L'invention concerne également un procédé de prévention, d'inhibition ou de traitement du cancer ou de ses métastases chez un sujet, par l'augmentation des formes adhésives de la cadhérine et/ou la diminution des formes non adhésives de la cadhérine sur la surface cellulaire.
Colman David R.
Gruzglin Eugenia
Maret Deborah
Seidah Nabil
Ircm (institut de Recherches Cliniques de Montreal)
Mount Sinai School Of Medicine
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
The Royal Institution For The Advancement Of Learning/mcgill Uni
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