C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/08 (2006.01) A61K 31/196 (2006.01) A61K 31/235 (2006.01) A61K 31/381 (2006.01) A61K 31/395 (2006.01) A61K 31/404 (2006.01) A61P 3/10 (2006.01) A61P 13/12 (2006.01) C07D 209/04 (2006.01) C07D 213/80 (2006.01) C07D 333/38 (2006.01)
Patent
CA 2692265
[Problems] To provide a compound that is useful as an agent for treating chronic renal insufficiency or an agent for treating diabetic nephropathy. [Means for Solving Problems] The present inventors have conducted extensive studies on a compound having an EP4 receptor antagonistic action, and as a result, they have found that various amide derivatives having a carboxylic group or an equivalent thereof exhibit an excellent EP4 receptor antagonistic action, thereby completing the present invention. Since the compound of the present invention has an excellent EP4 receptor antagonistic action, it is useful as an agent for preventing and/or treating chronic renal insufficiency or diabetic nephropathy.
L'invention concerne un composé utile comme agent thérapeutique contre l'insuffisance rénale chronique ou la néphropathie diabétique. A la suite d'une étude intensive et extensive sur des composés ayant des activités antagonistes sur les récepteurs EP4, on a découvert que divers dérivés amide portant chacun un groupe carboxyle ou un équivalent de celui-ci ont de bonnes activités antagonistes sur les récepteurs EP4. Les composés ont de bonnes activités antagonistes sur les récepteurs EP4, et sont par conséquent utiles comme agents prophylactiques et/ou thérapeutiques contre l'insuffisance rénale chronique ou la néphropathie diabétique.
Ibuka Ryotaro
Ikegai Kazuhiro
Matsuura Keisuke
Nozawa Eisuke
Seo Ryushi
Astellas Pharma Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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