Amide compounds and medicinal use thereof

Details Amide compounds and medicinal use thereof Amide compounds and medicinal use thereof

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/00 (2006.01) A61K 31/135 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/4155 (2006.01) A61K 31/422 (2006.01) A61K 31/438 (2006.01) A61K 31/454 (2006.01) A61K 31/496 (2006.01) A61K 31/5355 (2006.01) A61K 45/06 (2006.01) A61P 29/00 (2006.01) A61P 37/06 (2006.01) A61P 43/00 (2006.01) C07D 207/337 (2006.01) C07D 207/34 (2006.01) C07D 231/14 (2006.01) C07D 231/16 (2006.01) C07D 231/22 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/12 (2006.01) C07D 409/

Patent

CA 2362381

The present invention relates to a compound of the formula (see formula I) wherein R1 is substituted aryl, heteroaryl and the like, R2 and R3 are hydrogen, alkyl, halogen, hydroxyl group and the like, Q is N, CH and the like, W is hydrogen, alkyl, hydroxycarbonylalkyl and the like, X is halogen, cyano, nitro, amino and the like, X' is hydrogen, halogen, cyano, nitro, and Y is alkyl, hydroxyl group, alkoxy, mercapto and the like and a salt thereof, and a medicine containing the.said compound. The compound of the present invention shows a superior inhibitory effect on activated lymphocytes proliferation and is useful as an agent for the prophylaxis or treatment of various autoimmune diseases.

L'invention concerne des composés représentés par la formule générale (I) ou bien des sels de ceux-ci ainsi que des médicaments contenant ces composés, formule dans laquelle R<1> représente aryle substitué, hétéroaryle, etc.; R<2 >et R<3> représentent chacun hydrogène, alkyle, halogéno, hydroxy, etc.; Q représente N, CH, etc.; W représente hydrogène, alkyle, hydroxycarbonylalkyle, etc.; X représente hydrogène, halogéno, cyano ou nitro, amino, etc.; X' représente hydrogène, halogéno, cyano ou nitro; et Y représente alkyle, hydroxy, alcoxy, mercapt, etc. Etant donné qu'ils présentent un excellent effet d'inhibition de la prolifération de lymphocytes activés, ces médicaments sont utiles en tant qu'agents préventifs ou remèdes contre diverses maladies auto-immunes.

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