Amide derivatives as calcium channel blockers

Details Amide derivatives as calcium channel blockers Amide derivatives as calcium channel blockers

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4045 (2006.01) A61K 31/4468 (2006.01) A61K 31/454 (2006.01) A61P 9/00 (2006.01) A61P 25/04 (2006.01) A61P 25/08 (2006.01) C07C 237/24 (2006.01) C07D 209/14 (2006.01) C07D 211/66 (2006.01)

Patent

CA 2681118

Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted T-type calcium channel activity are disclosed. Specifically, a series of compounds containing both a diamide and aromatic functionality are disclosed of the general formula (I) where X1 and X2 are linkers.

L'invention concerne des procédés et des composés efficaces pour améliorer les états caractérisés par une activité indésirable du canal calcique, en particulier, l'activité indésirable du canal calcique de type T. Spécifiquement, l'invention concerne une série de composés contenant à la fois une fonctionnalité diamide et une fonctionnalité aromatique de formule générale (1), X1 et X2 étant des segments de liaison.

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