Amide derivatives as sirtuin modulators

Details Amide derivatives as sirtuin modulators Amide derivatives as sirtuin modulators

C - Chemistry, Metallurgy

07

D

C07D 239/42 (2006.01) A61K 31/44 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61P 3/10 (2006.01) C07D 213/81 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2704336

Provided herein are novel sirtuin-modulating compounds represented by Structural Formula (I) and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin- modulating compound in combination with another therapeutic agent.

L'invention porte sur de nouveaux composés modulateurs de sirtuines représentés par la formule structurale (I) et sur des procédés d'utilisation de ces composés. Les composés modulateurs de sirtuines peuvent être utilisés pour augmenter la durée de vie d'une cellule et traiter et/ou prévenir une large diversité de maladies et troubles comprenant, par exemple, les maladies ou troubles apparentés au vieillissement ou au stress, le diabète, l'obésité, les maladies neurodégénératives, la maladie cardiovasculaire, les troubles de la coagulation du sang, l'inflammation, le cancer et/ou les bouffées vasomotrices, ainsi que les maladies ou troubles qui bénéficieraient d'une activité mitochondriale accrue. L'invention porte également sur des compositions comprenant un composé modulateur des sirtuines en combinaison avec un autre agent thérapeutique.

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