C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 231/56 (2006.01) A61K 31/416 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2647545
The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly (ADP-ribose) polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes, neurodegenerative diseases, retroviral infection, retinal damage or skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment.
L'invention concerne des composés de formule (I), ainsi que des sels ou des tautomères de qualité pharmaceutique correspondants. L'action inhibitrice qu'exercent ces composés sur la poly(ADP-ribose)polymérase (PARP) explique leur efficacité dans le traitement du cancer, des maladies inflammatoires, des lésions de reperfusion, des états ischémiques, de l'accident vasculaire cérébral, de l'insuffisance rénale, des maladies cardiovasculaires, des maladies vasculaires autres que les maladies cardiovasculaires, le diabète, les maladies neurodégénératives, l'infection par rétrovirus, les dommages rétiniens ou la sénescence de la peau et les lésions cutanées provoquées par les U.V., ainsi que leur utilisation comme chimio- ou radiosensibilisants dans le traitement du cancer.
Boueres Julia Kay
Branca Danila
Ferrigno Federica
Jones Philip
Muraglia Ester
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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